Van de Ven Double Ends Everton's Run at Brand New Stadium
Micky van de Ven emerged as the initial defender to score two goals in a Premier League game for Spurs since the Belgian defender in March 2013.
Match summary
The Spurs defender heads home two times in first half
Everton's defender has equalizer ruled after VAR review
Pape Matar Sarr scores final goal in 89th minute
This loss is the Merseyside club's first at Hill Dickinson Stadium
The Tottenham defender scored twice as Spurs extended their winning streak on the road in the Premier League and delivered Everton their first defeat at their new home.
Everton were unbeaten in their last five matches at their recently opened stadium at Bramley-Moore Dock, having left Goodison Park behind after more than a century at the end of last season.
But Tottenham's leader the Dutchman pounced twice from corners in the opening 45 minutes to place their impressive record at jeopardy, and they were unable to turn it around before the midfielder - set up by ex-Everton forward the Brazilian - headed home a third to seal the victory.
The Everton defender believed he had equalized the scores five minutes after Van de Ven's opener, directing a bullet header past Guglielmo Vicario from an Everton corner.
The Portuguese striker, in the meantime, missed a handful of chances, while the Italian goalkeeper made a succession of excellent stops to guarantee Tottenham went five away games without defeat in the Premier League.
But the VAR stepped in, instructing Craig Pawson to review the goal on the pitchside monitor and the referee ruled that the winger and the attacker were in offside positions and had interfered with the Tottenham goalkeeper.
The win elevates Thomas Frank's side up to third in the Premier League, five points off local foes and leaders Arsenal.
Everton stay 14th and sit six points clear of the drop zone.
Spurs breakdown: The defender fulfils role at each end of pitch
After a uninspiring weekday display in the European competition against Monaco, where they managed a mere two shots on target, the manager chose the French striker up front instead of ex-Everton forward the Brazilian.
The summer signing was unable to make much of an impact before being replaced for Richarlison after 60 minutes on the field, but it emerged he wasn't needed in the final outcome.
Defender Van de Ven transformed into an attacking force to be reckoned with.
Tottenham's first goal came from a well-worked corner routine, with the midfielder heading the ball toward the face of goal for an unmarked Van de Ven to score.
And Ven de Ven - stepping up as skipper in the Argentine's unavailability - added his second in first-half stoppage time as he outjumped the England keeper to head home.
The Dutchman was just as outstanding in defensive duties, combining well with Kevin Danso as the pair dealt excellently with the numerous deliveries sent their way by the opposition.
Toffees breakdown: Everton missing finishing touch
Everton's recent stadium had been a fortress, but it appears the novelty may have worn off somewhat and supporters headed to the gates after the midfielder's final goal for Tottenham.
The end in Everton's unbeaten home run will not be a major concern for the manager, but their attacking woes will be.
Beto and Thierno Barry - the Toffees' pair of recognised strikers - had scored only a single goal between them before Sunday's match.
And they were failed to contribute to that miserable tally on a wet and gloomy night on in Liverpool.
The striker's form was epitomized when he opted to bicycle-kick a clear chance from close range, despite having space and opportunity to reposition for a simpler attempt that would have challenged Vicario.
The substitute, too, was unable to influence the game after replacing Beto in the 65th minute.
It was not for a lack of chance. The majority of the home side's offensive moves came through Grealish and Ndiaye, who tirelessly delivered dangerous balls into the Tottenham box.
Upcoming fixtures for these two sides?
The Toffees: Moyes' men head to the Stadium of Light in the top flight on Monday, 3 November at 20:00 GMT.
Spurs: The London club go to St James' Park on late October for their next round Carabao Cup match against Newcastle.